Conformational studies of Ant-Pro motif-incorporated cyclic peptides: gramicidin S and avellanin
| Title | Conformational studies of Ant-Pro motif-incorporated cyclic peptides: gramicidin S and avellanin |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Kotmale, AS, Sangtani, E, Gonnade, RG, Sarkar, D, Burade, S, Rajamohanan, PR, Sanjayan, GJ |
| Journal | New Journal of Chemistry |
| Volume | 42 |
| Issue | 2 |
| Pagination | 1197-1201 |
| Date Published | JAN |
| Abstract | This paper reports conformational changes observed in cyclic bioactive peptides such as gramicidin S and avellanin upon incorporation of a pseudo-beta (C9) Ant-(D)Pro turn motif in their structural frameworks. Solution-state studies suggested that a synthetic gramicidin S analog exhibits a beta-sheet conformation with C9 and C17 intramolecular hydrogen bonding patterns, while its truncated analog disturbs the beta-sheet conformation. Structural details were obtained using a combination of CD studies, X-ray crystal structure studies and nOe-based MD simulation studies. |
| DOI | 10.1039/c7nj03701e |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.269 |
Divison category:
Center for Material Characterization (CMC)
Central NMR Facility
Organic Chemistry