TY - JOUR T1 - Conformational studies of Ant-Pro motif-incorporated cyclic peptides: gramicidin S and avellanin JF - New Journal of Chemistry Y1 - 2018 A1 - Kotmale, Amol S. A1 - Sangtani, Ekta A1 - Gonnade, Rajesh G. A1 - Sarkar, Dhiman A1 - Burade, Sachin A1 - Rajamohanan, Pattuparambil R. A1 - Sanjayan, Gangadhar J. AB - This paper reports conformational changes observed in cyclic bioactive peptides such as gramicidin S and avellanin upon incorporation of a pseudo-beta (C9) Ant-(D)Pro turn motif in their structural frameworks. Solution-state studies suggested that a synthetic gramicidin S analog exhibits a beta-sheet conformation with C9 and C17 intramolecular hydrogen bonding patterns, while its truncated analog disturbs the beta-sheet conformation. Structural details were obtained using a combination of CD studies, X-ray crystal structure studies and nOe-based MD simulation studies. VL - 42 IS - 2 U3 - Foreign U4 - 3.269 ER -