Chemoenzymatic total synthesis of potent HIV RNase H inhibitor (-)-1,3,4,5-tetragalloylapiitol
| Title | Chemoenzymatic total synthesis of potent HIV RNase H inhibitor (-)-1,3,4,5-tetragalloylapiitol |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Batwal, RU, Patel, RM, Argade, NP |
| Journal | Tetrahedron-Asymmetry |
| Volume | 22 |
| Issue | 2 |
| Pagination | 173-177 |
| Date Published | JAN |
| ISSN | 0957-4166 |
| Abstract | Starting from racemic dimethyl 2-acetoxy-3-methylenesuccinate, the chemoenzymatic facile total synthesis of (-)-1,3,4,5-tetragalloylapiitol has been demonstrated via an efficient lipase catalyzed resolution followed by a DIBAL reduction-double gallyolation, osmium tetroxide dihydroxylation-double gallyolation, and reductive global O-benzyl deprotection pathway. (C) 2010 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetasy.2010.11.032 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.652 |
Divison category:
Organic Chemistry