TY - JOUR T1 - Chemoenzymatic total synthesis of potent HIV RNase H inhibitor (-)-1,3,4,5-tetragalloylapiitol JF - Tetrahedron-Asymmetry Y1 - 2011 A1 - Batwal, Ramesh U. A1 - Patel, Ramesh M. A1 - N. P. Argade AB -

Starting from racemic dimethyl 2-acetoxy-3-methylenesuccinate, the chemoenzymatic facile total synthesis of (-)-1,3,4,5-tetragalloylapiitol has been demonstrated via an efficient lipase catalyzed resolution followed by a DIBAL reduction-double gallyolation, osmium tetroxide dihydroxylation-double gallyolation, and reductive global O-benzyl deprotection pathway. (C) 2010 Elsevier Ltd. All rights reserved.

PB - PERGAMON-ELSEVIER SCIENCE LTD CY - THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND VL - 22 IS - 2 U3 - Foreign U4 - 2.652 ER -