Asymmetric transfer hydrogenation of imines in water by varying the ratio of formic acid to triethylamine
| Title | Asymmetric transfer hydrogenation of imines in water by varying the ratio of formic acid to triethylamine |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Shende, VS, Deshpande, SH, Shingote, SK, Joseph, A, Kelkar, AA |
| Journal | Organic Letters |
| Volume | 17 |
| Issue | 12 |
| Pagination | 2878-2881 |
| Date Published | JUN |
| ISSN | 1523-7060 |
| Abstract | Asymmetric transfer hydrogenation (ATH) of imines has been performed with variation in formic acid (F) and triethylamine (T) molar ratios in water. The F/T ratio is shown to affect both the reduction rate and enantioselectivity, with the optimum ratio being 1.1 in the ATH of imines with the Rh-(1S,2S)-TsDPEN catalyst. Use of methanol as a cosolvent enhanced reduction activity. A variety of imine substrates have been reduced, affording high yields (94-98%) and good to excellent enantioselectivities (89-98%). In comparison with the common azeotropic F-T system, the reduction with 1.1/1 F/T is faster. |
| DOI | 10.1021/acs.orglett.5b00889 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.732 |
Divison category:
Chemical Engineering & Process Development