%0 Journal Article %J Organic Letters %D 2015 %T Asymmetric transfer hydrogenation of imines in water by varying the ratio of formic acid to triethylamine %A Shende, Vaishali S. %A Deshpande, Sudhindra H. %A Shingote, Savita K. %A Joseph, Anu %A Kelkar, Ashutosh A. %X

Asymmetric transfer hydrogenation (ATH) of imines has been performed with variation in formic acid (F) and triethylamine (T) molar ratios in water. The F/T ratio is shown to affect both the reduction rate and enantioselectivity, with the optimum ratio being 1.1 in the ATH of imines with the Rh-(1S,2S)-TsDPEN catalyst. Use of methanol as a cosolvent enhanced reduction activity. A variety of imine substrates have been reduced, affording high yields (94-98%) and good to excellent enantioselectivities (89-98%). In comparison with the common azeotropic F-T system, the reduction with 1.1/1 F/T is faster.

%B Organic Letters %I AMER CHEMICAL SOC %C 1155 16TH ST, NW, WASHINGTON, DC 20036 USA %V 17 %P 2878-2881 %8 JUN %G eng %N 12 %3

Foreign

%4 6.732 %R 10.1021/acs.orglett.5b00889