Assessing the effect of different shapes of glyco-gold nanoparticles on bacterial adhesion and infections

TitleAssessing the effect of different shapes of glyco-gold nanoparticles on bacterial adhesion and infections
Publication TypeJournal Article
Year of Publication2015
AuthorsChaudhary, PMadhukar, Sangabathuni, S, Murthy, RVasudeva, Paul, A, Thulasiram, HV, Kikkeri, R
JournalChemical Communications
Volume51
Issue86
Pagination15669-15672
Date PublishedAUG
ISSN1359-7345
Abstract

Achieving selective and sensitive carbohydrate-protein interactions (CPIs) using nanotechnology is an intriguing area of research. Here we demonstrate that the different shapes of gold nanoparticles (AuNPs) functionalized with monosaccharides tune the bacterial aggregations. The mechanism of aggregation revealed that the large number of surface interactions of rod shaped mannose-AuNPs with E. coli ORN 178 compared with spherical and star-shaped AuNPs exhibited higher avidity and sensitivity. Moreover, such sensitive binding can be used for effective inhibition of bacterial infection of cells.

DOI10.1039/c5cc05238f
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)6.567
Divison category: 
Organic Chemistry