Angiotensin II analogs comprised of pro-amb (gamma-turn scaffold) as angiotensin II type 2 (AT(2)) receptor agonists
| Title | Angiotensin II analogs comprised of pro-amb (gamma-turn scaffold) as angiotensin II type 2 (AT(2)) receptor agonists |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Jedhe, GS, Kotmale, AS, Rajamohanan, PR, Pasha, S, Sanjayan, GJ |
| Journal | Chemical Communications |
| Volume | 52 |
| Issue | 8 |
| Pagination | 1645-1648 |
| Date Published | NOV |
| ISSN | 1359-7345 |
| Abstract | We describe herein the design, synthesis and conformational investigation of Pro-Amb (proline-3-amino-2-methoxybenzoic acid) incorporated Angiotensin II and its truncated analogues. Solution-state NMR and CD studies suggest gamma-turn-like conformation in Pro-Amb analogs in aqueous solution. Furthermore, Pro-Amb analogs have been shown to act as AT(2) receptor agonists. |
| DOI | 10.1039/c5cc09687a |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.567 |
Divison category:
Central NMR Facility
Organic Chemistry