01207nas a2200193 4500008004100000022001400041245012100055210006900176260011000245300001400355490000700369520038400376100002200760700002200782700003500804700001900839700002800858856012700886 2016 eng d a1359-734500aAngiotensin II analogs comprised of pro-amb (gamma-turn scaffold) as angiotensin II type 2 (AT(2)) receptor agonists0 aAngiotensin II analogs comprised of proamb gammaturn scaffold as aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcNOV a1645-16480 v523 a
We describe herein the design, synthesis and conformational investigation of Pro-Amb (proline-3-amino-2-methoxybenzoic acid) incorporated Angiotensin II and its truncated analogues. Solution-state NMR and CD studies suggest gamma-turn-like conformation in Pro-Amb analogs in aqueous solution. Furthermore, Pro-Amb analogs have been shown to act as AT(2) receptor agonists.
1 aJedhe, Ganesh, S.1 aKotmale, Amol, S.1 aRajamohanan, Pattuparambil, R.1 aPasha, Santosh1 aSanjayan, Gangadhar, J. uhttp://library.ncl.res.in/content/angiotensin-ii-analogs-comprised-pro-amb-gamma-turn-scaffold-angiotensin-ii-type-2-at2-0