Autoantibodies against Nε-carboxymethyl lysine and methylglyoxal modified albumin are associated with cardiovascular risk in type 2 diabetes
| Title | Autoantibodies against Nε-carboxymethyl lysine and methylglyoxal modified albumin are associated with cardiovascular risk in type 2 diabetes |
| Publication Type | Journal Article |
| Year of Publication | 2025 |
| Authors | Patil, YR, Tiwari, S, Momin, AA, Unnikrishnan, AG, Kulkarni, MJ |
| Journal | International Journal of Diabetes in Developing Countries |
| Volume | 45 |
| Issue | 4 |
| Pagination | 1104-1110 |
| Date Published | DEC |
| Type of Article | Article |
| ISSN | 0973-3930 |
| Keywords | AGE, Atherosclerosis, Diabetes, Glycation, Immune response, ROC |
| Abstract | {Background Albumin is an abundant plasma protein which gets modified with advanced glycation end products (AGEs) predominantly in diabetic condition. AGE modification induces immune response and autoantibodies are generated which play an important role in disease pathology. Objective This study aimed to illustrate the role of autoantibodies against N epsilon-carboxymethyl lysine (CML) and methylglyoxal (MG) modified albumin in diabetic cardiovascular complications. MethodsType-2 diabetes subjects were enrolled and further grouped into stress test positive or stress test negative based on treadmill stress test (TMT). Autoantibody titer was quantified by ELISA assay for CML-modified albumin (stress test positive |
| DOI | 10.1007/s13410-024-01435-0 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 0.8 |
Divison category:
Biochemical Sciences
Database:
Web of Science (WoS)
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