Cu-catalyzed multicomponent reaction of arylhydrazines with β-ketoesters and TBN: one-pot access to N 2-aryl 1,2,3-triazole-1-oxides
| Title | Cu-catalyzed multicomponent reaction of arylhydrazines with β-ketoesters and TBN: one-pot access to N 2-aryl 1,2,3-triazole-1-oxides |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Mujahid, M, Vara, V, Arshad, U, Gamidi, RKrishna, Muthukrishnan, M |
| Journal | Journal of Organic Chemistry |
| Volume | 89 |
| Issue | 23 |
| Pagination | 16990-16998 |
| Date Published | NOV |
| Type of Article | Article |
| ISSN | 0022-3263 |
| Abstract | We report a copper-catalyzed one-pot, multicomponent strategy for the convenient synthesis of N 2-aryl 1,2,3-triazole-1-oxides using arylhydrazines, beta-ketoesters, and tert-butyl nitrite. This mild and simple reaction proceeds in an atom-economic manner with broad substrate scope, affording a variety of N 2-aryl 1,2,3-triazole-1-oxide derivatives. Other salient features of the reaction are good functional group tolerance, scalability, and product diversification. |
| DOI | 10.1021/acs.joc.4c00298 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.6 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)