Synthesis and antimycobacterial screening of a novel series of alpha-amino acids containing thiazole linker
| Title | Synthesis and antimycobacterial screening of a novel series of alpha-amino acids containing thiazole linker |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Nalawade, JL, Mhaske, PC, Shinde, AD, Chavan, AP, Abhale, YK, Sarkar, D, Bobade, VD |
| Journal | ARKIVOC |
| Type of Article | Article |
| ISSN | 1551-7004 |
| Keywords | Amino acid, antibacterial activity, Cytotoxicity, Mycobacterium tuberculosis, synthesis, Thiazole |
| Abstract | A small focused library of uncommon (S)-2-amino-3-(4-(((4-methyl-2-arylthiazol-5-yl)methyl)amino)phenyl) propanoic acid (5a-e) and (S)-2-amino-3-(4-(((2-arylthiazol-4-yl)methyl)amino)phenyl)propanoic acid (9a-d) derivatives have been efficiently synthesized by employing molecular simplification. The title compounds were screened for inhibitory activity against Mycobacterium tuberculosis H37Ra (MTB) and Mycobacterium bovis (BCG) strains. The cytotoxicity study was conducted against primary Human Umbilical Vein Endothelial Cells (HUVECs), on two different human tumor cells HeLa, and HCT 116 and was observed non-toxic to host cells. |
| DOI | 10.24820/ark.5550190.p011.831 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 0.689 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)
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