Tandem acceptorless dehydrogenative coupling-decyanation under nickel catalysis
| Title | Tandem acceptorless dehydrogenative coupling-decyanation under nickel catalysis |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Midya, SP, Subaramanian, M, Babu, R, Yadav, V, Balaraman, E |
| Journal | Journal of Organic Chemistry |
| Volume | 86 |
| Issue | 11 |
| Pagination | 7552-7562 |
| Date Published | JUN |
| Type of Article | Article |
| ISSN | 0022-3263 |
| Abstract | The development of new catalytic processes based on abundantly available starting materials by cheap metals is always a fascinating task and marks an important transition in the chemical industry. Herein, a nickel-catalyzed acceptorless dehydrogenative coupling of alcohols with nitriles followed by decyanation of nitriles to access diversely substituted olefins is reported. This unprecedented C=C bond-forming methodology takes place in a tandem manner with the formation of formamide as a sole byproduct. The significant advantages of this strategy are the low-cost nickel catalyst, good functional group compatibility (ether, thioether, halo, cyano, ester, amino, N/O/S heterocycles; 43 examples), synthetic convenience, and high reaction selectivity and efficiency. |
| DOI | 10.1021/acs.joc.1c00592 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.354 |
Divison category:
Organic Chemistry