Short review of synthetic routes for the antiepileptic drug (R)-lacosamide
| Title | Short review of synthetic routes for the antiepileptic drug (R)-lacosamide |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Aratikatla, EK, Bhattacharya, AK |
| Journal | Organic Process Research & Development |
| Volume | 24 |
| Issue | 1 |
| Pagination | 17-24 |
| Date Published | JAN |
| Type of Article | Review |
| ISSN | 1083-6160 |
| Keywords | antiepileptic drug, epilepsy, lacosamide, serine derivative, synthesis |
| Abstract | The disease epilepsy affects people of all ages and is due to a chronic neurological disorder in the brain. According to a report by the World Health Organization, epilepsy is one of the most common global neurological diseases. (R)-Lacosamide (Vimpat) was introduced by UCB Pharma in 2008 for the treatment of partial-onset seizures in patients suffering from epilepsy. This review summarizes all of the available synthetic strategies reported for (R)-lacosamide, which will help medicinal chemists in the further development of its synthesis. |
| DOI | 10.1021/acs.oprd.9b00373 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.023 |
Divison category:
Organic Chemistry