Synthesis of alpha-ketoamides using potassium superoxide (KO2) as an oxidizing agent
| Title | Synthesis of alpha-ketoamides using potassium superoxide (KO2) as an oxidizing agent |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Vasudevan, N, Routholla, G, Illa, GTeja, D. Reddy, S |
| Journal | Tetrahedron |
| Volume | 76 |
| Issue | 25 |
| Pagination | 131262 |
| Date Published | JUN |
| Type of Article | Article |
| ISSN | 0040-4020 |
| Keywords | alpha-Ketoamide, Orexin receptor, Oxidation, Potassium superoxide (KO2) |
| Abstract | A simple and convenient method for the synthesis of alpha-ketoamides by the oxidation of aryl acetamides using potassium superoxide (KO2) as an oxidizing agent is disclosed here. The scope of the developed method is successfully tested with fifteen substrates. In addition, the utility of method has been demonstrated by synthesizing an orexin receptor antagonist, a medicinally interesting compound. (C) 2020 Published by Elsevier Ltd. |
| DOI | 10.1016/j.tet.2020.131262 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.233 |
Divison category:
Organic Chemistry
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