Total synthesis and absolute configuration determination of Ktedonoketone, a benzenoid metabolite from Thermophilic bacterium
| Title | Total synthesis and absolute configuration determination of Ktedonoketone, a benzenoid metabolite from Thermophilic bacterium |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Dandawate, M, Choudhury, R, Krishna, GRama, D. Reddy, S |
| Journal | Tetrahedron Letters |
| Volume | 61 |
| Issue | 47 |
| Pagination | 152526 |
| Date Published | NOV |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Keywords | Absolute configuration, Ktedonoketone, Total synthesis, Wacker oxidation |
| Abstract | The successful total synthesis of both enantiomers of ktedonoketone allowed us to decipher an unambiguous assignment of absolute configuration of the natural product. The concise synthesis highlights Wacker oxidation and aldol condensation as key steps. In addition to this, the current synthetic route is suitable to access a library of compounds on the similar skeleton as one can use readily available amino acids and Grignard reagents as variants. (C) 2020 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2020.152526 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.275 |
Divison category:
Organic Chemistry
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