Protecting group free and scalable approach towards total synthesis of (-)-venlafaxine
| Title | Protecting group free and scalable approach towards total synthesis of (-)-venlafaxine |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Chavan, SP, Pawar, KP, Garai, S |
| Journal | RSC Advances |
| Volume | 4 |
| Issue | 28 |
| Pagination | 14468-14470 |
| Date Published | FEB |
| Type of Article | Article |
| ISSN | 2046-2069 |
| Abstract | A protecting group free asymmetric total synthesis of (-)-venlafaxine is reported. The strategy employs Sharpless epoxidation and regio-selective epoxide ring opening by an in situ generated Gilman reagent as key steps. This paper reports a 53% overall yield in 6 steps for total synthesis of (-)-venlafaxine. |
| DOI | 10.1039/c4ra00840e |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.289 |
Divison category:
Organic Chemistry