Telescoped sequence of exothermic and endothermic reactions in multistep flow synthesis
| Title | Telescoped sequence of exothermic and endothermic reactions in multistep flow synthesis |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Sharma, Y, Nikam, AV, Kulkarni, AA |
| Journal | Organic Process Research and Development |
| Pagination | Article ASAP |
| Date Published | JAN |
| Type of Article | Article |
| Abstract | A multistep sequential flow synthesis of isopropyl phenol is demonstrated, involving 4-step exothermic, endothermic, and temperature sensitive reactions such as nitration, reduction, diazotization, and high temperature hydrolysis. Nitration of cumene with fuming nitric acid produces 2- and 4-nitrocumene which are converted into respective cumidines by the hydrogenation using Pd/Ni catalyst in H-cube with gravity separation. Hydrolysis of in situ generated diazonium salts in the boiling acidic conditions is carried out using integration of flow and microwave-assisted synthesis. 58% of 4-isopropyl phenol was obtained. The sequential flow synthesis can be applied to synthesize other organic compounds involving this specific sequence of reactions. |
| DOI | 10.1021/acs.oprd.8b00008 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.584 |
Divison category:
Chemical Engineering & Process Development
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