Scalable synthesis of both enantiomers of vigabatrin, an antiepileptic drug

TitleScalable synthesis of both enantiomers of vigabatrin, an antiepileptic drug
Publication TypeJournal Article
Year of Publication2019
AuthorsJachak, GR, Reddy, DS
JournalEuropean Journal of Organic Chemistry
Issue6
Pagination1257–1260
Date PublishedFEB
Type of ArticleArticle
Abstract

Vigabatrin is a potent inhibitor of gamma‐aminobutyric acid (GABA) catabolism used for the treatment of epilepsy. Here we have synthesized both enantiomers of the drug vigabatrin in five steps from known intermediates using Wittig olefination and pyrolytic elimination as key steps. The target compounds are synthesized in gram scale amounts with >98 % enantiopurity.
DOI10.1002/ejoc.201801617
Type of Journal (Indian or Foreign)

Foreign
Impact Factor (IF)

2.882
Divison category: 
Organic Chemistry

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