One-pot sequential bromination and fluorination to access 3-fluoroimidazo[1,2-a]pyridines from arylketones
| Title | One-pot sequential bromination and fluorination to access 3-fluoroimidazo[1,2-a]pyridines from arylketones |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Udavant, RN, Yadav, AR, Shinde, SS |
| Journal | European Journal Of Organic Chemistry |
| Volume | 2018 |
| Issue | 26 |
| Pagination | 3432-3436 |
| Date Published | JUL |
| Type of Article | Article |
| ISBN Number | 1434193X |
| Abstract | 3-Fluoro-2-arylimidazo[1,2-a]pyridines were selectively synthesised in one-pot from acetophenones and 2-aminopyridines under mild conditions. The sequence of reactions involved bromination, condensation, and late-stage fluorination. Two halogenating reagents play key roles in the process. We found that tetrabutylammonium tribromide and SelectfluorTM gave excellent yields of the desired products in the one-pot sequential reaction. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
| DOI | 10.1002/ejoc.201800578 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.882 |
Divison category:
Organic Chemistry
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