Flexible and free-standing reduced graphene oxide thick films with PMMA stabilized silver nanoparticles, as a potential probe for cancer thermal therapy
| Title | Flexible and free-standing reduced graphene oxide thick films with PMMA stabilized silver nanoparticles, as a potential probe for cancer thermal therapy |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Asha, S, A. Ananth, N, Jose, SP, Rajan, MAJ |
| Journal | Biomedical physics and engineering express |
| Volume | 4 |
| Issue | 6 |
| Pagination | 65032 |
| Date Published | OCT |
| Type of Article | Article |
| Abstract | hermal therapy is an efficient, cost-effective method for treating different types of cancers and hence flexible, light weight, biocompatible heating materials with low power consumption are of utmost importance. Partially reduced flexible, robust and bio-compatible thick graphene oxide films with, mostly edge functionalized Polymethyl methacrylate (PMMA) and in situ grown silver nanoparticles were prepared using simple soak and dry strategy. Larger distribution of silver nanoparticles with a mean diameter of 2.5 nm were anchored towards the edges of these thick films. The electrothermal (Joule heating) performance were found to increase in the presence of silver nanoparticles due to decrease in sheet resistance (0.33 × 104 Ωm) and increase in electron-phonon interaction. These free-standing, flexible films exhibited stable Joule heating behavior under repeated voltage on/off cycles. In-vitro studies performed on breast cancer cells in the presence of the prepared films, with an external applied voltage of 10 VDC, shows 67% cell death. This work proves the potentiality of thick heterogeneous (partially) reduced graphene oxide films towards site specific destruction of solid tumors by utilizing its Joule heating properties. |
| DOI | 10.1088/2057-1976/aae90c |
| Type of Journal (Indian or Foreign) | Foreign |
Divison category:
Chemical Engineering & Process Development
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