Cucurbit[7]uril induced formation of fret-enabled unilamellar lipid vesicles
| Title | Cucurbit[7]uril induced formation of fret-enabled unilamellar lipid vesicles |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Kushwaha, S, Maity, A, Gangopadhyay, M, Ravindranathan, S, Rajamohanan, PR, Das, A |
| Journal | Langmuir |
| Volume | 33 |
| Issue | 41 |
| Pagination | 10989-10999 |
| Date Published | OCT |
| Type of Article | Article |
| Abstract | A unique fluorescence resonance energy transfer (FRET) process is found to be operational in a unilamellar lipid self-assembly in the aqueous phase. A newly synthesized naphthyl based long chain lipid derivative [N-(naphthalene-1-ylmethyl)tetradecane-1-ammonium chloride, 14NA(+)] forms various self-assembled architectures in the aqueous phase. Controlled changes in lipid concentration lead to a transition of the self-assemblies from micelles to vesicles to rods. In the presence of cucurbit[7]uril (CB7), 14NA(+) forms a host-guest [2]pseudorotaxane complex (CB7(sic)14NA(+)) and secondary interactions lead to the formation of a lipid bilayer with hydrophobic pockets situated in between the layers. The change in the structure of 14NA(+) assemblies, interaction with CB7 and formation of supramolecular assemblies of CB7(sic)14NA(+) were examined using light scattering, spectroscopic, and microscopic techniques. Entrapment of a luminescent dye, anthracene within the hydrophobic bilayer of the supramolecular assembly CB7(sic)14NA(+) favors a modified luminescent response due to an efficient FRET process. Further, the FRET process could be controlled by thermal and chemical stimuli that induce transformation of unilamellar vesicles. |
| DOI | 10.1021/acs.langmuir.7b02777 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.833 |
Divison category:
Central NMR Facility
Organic Chemistry