Organocatalyzed efficient one-pot synthesis, biological evaluation, and molecular docking studies of 4,4-(Arylmethylene)bis-(3-methyl-1-phenyl-1H-pyrazol-5-ols)

TitleOrganocatalyzed efficient one-pot synthesis, biological evaluation, and molecular docking studies of 4,4-(Arylmethylene)bis-(3-methyl-1-phenyl-1H-pyrazol-5-ols)
Publication TypeJournal Article
Year of Publication2017
AuthorsMahajan, PS, Nikam, MD, Khedkar, V, Jha, P, Badadhe, PV, Gill, CH
JournalJournal of Heterocyclic Chemistry
Volume54
Issue2
Pagination1109-1120
Date PublishedMAR
AbstractThe synthesis of 4,4-(arylmethylene)bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol) derivatives catalyzed by ?-proline is a simple, versatile, and efficient method. In vitro antioxidant, anti-inflammatory, and antimicrobial activities of compounds 4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j were studied. Furthermore, to rationalize the observed anti-inflammatory activity data, molecular docking study has been performed against COX-2 enzyme which revealed a good binding affinity for these molecules and could provide an insight into the various bonded and non-bonded interactions guiding their binding affinity.
DOI10.1002/jhet.2681
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)0.685
Divison category: 
Organic Chemistry

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