Synthesis of extended conjugated indolyl chalcones as potent anti-breast cancer, anti-inflammatory and antioxidant agents
| Title | Synthesis of extended conjugated indolyl chalcones as potent anti-breast cancer, anti-inflammatory and antioxidant agents |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Bhale, PS, Chavan, HV, Dongare, SB, Shringare, SN, Mule, YB, Nagane, SS, Bandgar, BP |
| Journal | Bioorganic & Medicinal Chemistry Letters |
| Volume | 27 |
| Issue | 7 |
| Pagination | 1502-1507 |
| Date Published | APR |
| Abstract | In the present investigation, synthesis of a series of extended conjugated delta-chloro-alpha-cyano substituted indolyl chalcones (5a-p) was accomplished by reacting 3-cyanoacetylindole 2 with 3-chloro-3-phenylpropenal 4 in the presence of piperidine. The structural interpretations of newly synthesized compounds were based on chemical and spectroscopic evidences. Anti-tumor evaluation of the synthesized compounds in vitro against MCF-7 (breast carcinoma) cell line revealed that they possess high anti-tumor activities. Among them, compound 5e and 5a demonstrated excellent activity against breast carcinoma (GI(50) |
| DOI | 10.1016/j.bmcl.2017.02.052 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.486 |
Divison category:
Polymer Science & Engineering