Facile synthesis of N-acyl 2-aminobenzothiazoles by NHC-catalyzed direct oxidative amidation of aldehydes
| Title | Facile synthesis of N-acyl 2-aminobenzothiazoles by NHC-catalyzed direct oxidative amidation of aldehydes |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Premaletha, S, Ghosh, A, Joseph, S, Reddy, SVardhan, Biju, AT |
| Journal | Chemical Communications |
| Volume | 53 |
| Issue | 9 |
| Pagination | 1478 - 1481 |
| Date Published | JAN |
| Abstract | A mild, general, and high yielding synthesis of N-acyl 2-aminobenzothiazoles has been demonstrated by N-heterocyclic carbene (NHC)-organocatalyzed direct amidation of aldehydes with 2-aminobenzothiazoles proceeding via acyl azolium intermediates. The carbene generated from the triazolium salt under oxidative conditions was the key for the success of this reaction. The method was subsequently applied to the synthesis of various biologically important N-acyl 2-aminobenzothiazoles. |
| DOI | 10.1039/C6CC08640C |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.567 |
Divison category:
Organic Chemistry