Synthesis of small cyclic peptides constrained with 3-(3-aminomethylphenyl)propionic acid linkers using free radical-mediated macrocyclization
| Title | Synthesis of small cyclic peptides constrained with 3-(3-aminomethylphenyl)propionic acid linkers using free radical-mediated macrocyclization |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Balraju, V, D. Reddy, S, Periasamy, M, Iqbal, J |
| Journal | Tetrahedron Letters |
| Volume | 46 |
| Issue | 31 |
| Pagination | 5207-5210 |
| Date Published | AUG |
| Abstract | In this letter, we report that small peptides (di- and tri-) having a 3-bromobenzyl group at the C-termini and an acryloyl group at the N-termini undergo an efficient Bu3SnH-AlBN mediated intramolecular free radical cyclization to afford cyclic peptides in good yields. We also propose that these cyclizations are occurring via a pre-organized acyclic structure dictated by a reverse turn (gamma/beta-turn). (c) 2005 Published by Elsevier Ltd. |
| DOI | 10.1016/j.tetlet.2005.05.115 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Organic Chemistry