Cobalt-catalyzed bis-alkynylation of amides via double C–H bond activation
| Title | Cobalt-catalyzed bis-alkynylation of amides via double C–H bond activation |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Landge, VGokulkrish, Jaiswal, G, Balaraman, E |
| Journal | Organic Letters |
| Volume | 18 |
| Issue | 4 |
| Pagination | 812–815 |
| Date Published | FEB |
| Abstract | The first example of cobalt-catalyzed selective bis-alkynylation of amides via double C–H bond activation with the directing assistance of a removable bidentate auxiliary is reported. The developed alkynylation strategy is simple, efficient, and tolerant of various functional groups including ether, amine, halides, and heterocyclic motifs. The reaction can be scaled up under mild conditions. |
| DOI | 10.1021/acs.orglett.6b00095 |
| Funding Agency | Council of Scientific & Industrial Research (CSIR) - India |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.732 |
Divison category:
Catalysis and Inorganic Chemistry