Synthesis of functionalized coumarins and quinolinones by NHC-catalyzed annulation of modified enals with heterocyclic C-H acids
| Title | Synthesis of functionalized coumarins and quinolinones by NHC-catalyzed annulation of modified enals with heterocyclic C-H acids |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Yetra, SReddy, Roy, T, Bhunia, A, Porwal, D, Biju, AT |
| Journal | Journal of Organic Chemistry |
| Volume | 79 |
| Issue | 9 |
| Pagination | 4245–4251 |
| Date Published | APR |
| Abstract | N-Heterocyclic carbene (NHC) catalyzed lactonization and lactamization of 2-bromoenals with heterocyclic C–H acids proceeding via the α,β-unsaturated acyl azolium intermediates is reported. The reaction furnished coumarin- or quinolinone-fused lactone/lactam derivatives. In addition, results of the enantioselective version of this reaction using chiral NHC are presented. |
| DOI | 10.1021/jo500693h |
| Funding Agency | Council of Scientific & Industrial Research (CSIR) - India |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 5.22 |
Divison category:
Organic Chemistry