Concise synthesis of beta-blockers (S)-metoprolol and (S)-betaxolol using hydrolytic kinetic resolution
| Title | Concise synthesis of beta-blockers (S)-metoprolol and (S)-betaxolol using hydrolytic kinetic resolution |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Muthukrishnan, M, Garud, DR, Joshi, RR, Joshi, RA |
| Journal | Tetrahedron |
| Volume | 63 |
| Issue | 8 |
| Pagination | 1872-1876 |
| Date Published | FEB |
| Type of Article | Article |
| ISSN | 0040-4020 |
| Keywords | beta-blockers, betaxolol, Hydrolytic kinetic resolution, metoprolol |
| Abstract | Enantiopure (S)-metoprolol and (S)-betaxolol were prepared in an extremely simple and practical way using Jacobsen's hydrolytic kinetic resolution of terminal epoxides in isopropanol. (c) 2007 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tet.2006.12.016 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.645 |
Divison category:
Organic Chemistry