Efficient strategy for the construction of both enantiomers of the octahydropyrroloquinolinone ring system: total synthesis of (+)-aspidospermidine
| Title | Efficient strategy for the construction of both enantiomers of the octahydropyrroloquinolinone ring system: total synthesis of (+)-aspidospermidine |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Pandey, G, Burugu, SKumar, Singh, P |
| Journal | Organic Letters |
| Volume | 18 |
| Issue | 7 |
| Pagination | 1558-1561 |
| Date Published | APR |
| ISSN | 1523-7060 |
| Abstract | An efficient and highly stereoselective intramolecular [3 + 2] cycloaddition of nonstabilized azomethine ylide generated from a designed bicyclic aminal precursor is reported for the synthesis of both (-)- and (+)-octahy-dropyrroloquinolinone. One of the enantiomers is further advanced to accomplish the total synthesis of (+)-aspidospermidine. |
| DOI | 10.1021/acs.orglett.6b00374 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.732 |
Divison category:
Organic Chemistry