Organocatalytic route to enantioselective synthesis of ceramide trafficking inhibitor HPA-12
| Title | Organocatalytic route to enantioselective synthesis of ceramide trafficking inhibitor HPA-12 |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Lalwani, KG, Sudalai, A |
| Journal | Tetrahedron Letters |
| Volume | 57 |
| Issue | 22 |
| Pagination | 2445-2447 |
| Date Published | JUN |
| ISSN | 0040-4039 |
| Keywords | alpha-Amination, CBS reduction, Ceramide, Organocatalytic, Proline |
| Abstract | A new organocatalytic approach to the synthesis of ceramide trafficking inhibitor HPA-12 has been described starting from phenacyl bromide. The strategy involves chiral CBS reduction of gamma-ketoester and proline-catalyzed alpha-amination reaction of aldehyde followed by reduction as the key chirality inducing steps. (C) 2016 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2016.04.087 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Chemical Engineering & Process Development