Chemoenzymatic access to (+)-artabotriol and its application in collective synthesis of (+)-grandiamide D, (-)-tulipalin B, (+)-spirathundiol, and (+)-artabotriolcaffeate
| Title | Chemoenzymatic access to (+)-artabotriol and its application in collective synthesis of (+)-grandiamide D, (-)-tulipalin B, (+)-spirathundiol, and (+)-artabotriolcaffeate |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Batwal, RU, Argade, NP |
| Journal | Synthesis-Stuttgart |
| Volume | 48 |
| Issue | 13 |
| Pagination | 2130-2136 |
| Date Published | JUL |
| ISSN | 0039-7881 |
| Keywords | (+)-artabotriol, collective synthesis, coupling reactions, dimethyl (+/-)-2-hydroxy-3-methylenesuccinate, Enzymatic resolution, Natural products, reduction |
| Abstract | Starting from dimethyl (+/-)-2-hydroxy-3-methylenesuccinnate chemoenzymatic collective formal/total synthesis of enantiomerically pure bioactive natural products has been described via the advanced level common precursor (+)-artabotriol. An efficient enzymatic resolution with high enantiomeric purity, selective diester to diol reduction, and requisite dehydrative coupling reactions without any racemization are the significant topographies. |
| DOI | 10.1055/s-0035-1561588 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.652 |
Divison category:
Organic Chemistry