Wittig-horner approach for the synthesis of tamoxifen
| Title | Wittig-horner approach for the synthesis of tamoxifen |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Pandey, RK, Wakharkar, RD, Kumar, P |
| Journal | Synthetic Communications |
| Volume | 35 |
| Issue | 21 |
| Pagination | 2795-2800 |
| Date Published | MAY |
| Type of Article | Article |
| ISSN | 0039-7911 |
| Keywords | anticancer drug, phosphonate, stereoselectivity, Tamoxifen, Wittig-Horner reaction |
| Abstract | A stereoselective synthesis of Z -tamoxifen, a tetra-substituted alkene with antiestrogenic activity, is described. The Wittig-Horner reaction has been employed as the key step to establish the olefin stereochemistry. |
| DOI | 10.1080/00397910500290516 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.065 |
Divison category:
Organic Chemistry