Asymmetric synthesis of aryloxypropanolamines via OsO4-catalyzed asymmetric dihydroxylation
| Title | Asymmetric synthesis of aryloxypropanolamines via OsO4-catalyzed asymmetric dihydroxylation |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Sayyed, IA, Thakur, VV, Nikalje, MD, Dewkar, G, Kotkar, SP, Sudalai, A |
| Journal | Tetrahedron |
| Volume | 61 |
| Issue | 11 |
| Pagination | 2831-2838 |
| Date Published | MAR |
| ISSN | 0040-4020 |
| Keywords | antihypertensive, asymmetric dihydroxylation, cyclic sulfates, epoxides |
| Abstract | A simple and effective procedure for the enantioselective synthesis of several beta-adrenergic blocking agents incorporating the first asymmetric synthesis of celiprolol, is described. The key steps are (i) sharpless asymmetric dihydroxylation of aryl allyl ethers to introduce chirality into the molecules and (ii) conversion of cyclic sulfates into the corresponding epoxides using a three-step procedure. (c) 2005 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tet.2005.01.074 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.645 |
Divison category:
Chemical Engineering & Process Development