Trans-5-Aminopipecolyl-aegPNA chimera: design, synthesis, and study of binding preferences with DNA/RNA in duplex/triplex mode
| Title | Trans-5-Aminopipecolyl-aegPNA chimera: design, synthesis, and study of binding preferences with DNA/RNA in duplex/triplex mode |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Lonkar, PS, Kumar, VA |
| Journal | Journal of Organic Chemistry |
| Volume | 70 |
| Issue | 17 |
| Pagination | 6956-6959 |
| Date Published | AUG |
| Type of Article | Article |
| ISSN | 0022-3263 |
| Abstract | [GRAPHICS] The design and synthesis of novel chiral PNA monomer based on traps-5-aminopipecolic acid is reported. The trans diequatorial disposition of the 1,4 ring substituents in six-membered 5-aminopipecolic acid derivative could be favorable over trans 1,3 axial-equatorial disposition in 4-amino-pipecolic acid of PNA. Studies on the synthesis of traps-4/ 5-aminopipecolyl PNA-eagPNA chimeras and their binding preferences to DNA/RNA in duplex/triplex modes are described. |
| DOI | 10.1021/jo0506884 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.785 |
Divison category:
Organic Chemistry