Convenient synthesis of the enantiomerically pure beta-blocker (S)-betaxolol using hydrolytic kinetic resolution
Title | Convenient synthesis of the enantiomerically pure beta-blocker (S)-betaxolol using hydrolytic kinetic resolution |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Joshi, RA, Garud, DR, Muthukrishnan, M, Joshi, RR, Gurjar, MK |
Journal | Tetrahedron-Asymmetry |
Volume | 16 |
Issue | 23 |
Pagination | 3802-3806 |
Date Published | NOV |
Type of Article | Article |
ISSN | 0957-4166 |
Abstract | Enantiopure (S)-betaxolol was prepared in an extremely simple and practical way using hydrolytic kinetic resolution of a terminal epoxide by Jacobsen's catalyst. High enantiomeric purity (99% ee) has been achieved and the method is amenable to industrial scale-up. (c) 2005 Elsevier Ltd. All rights reserved. |
DOI | 10.1016/j.tetasy.2005.10.028 |
Type of Journal (Indian or Foreign) | Foreign |
Impact Factor (IF) | 2.108 |
Divison category:
Organic Chemistry