Novel enzymatic route for kinetic resolution of (+/-)1,4-benzodioxan-2-carboxylic acid
| Title | Novel enzymatic route for kinetic resolution of (+/-)1,4-benzodioxan-2-carboxylic acid |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Kasture, SM, Varma, R, Kalkote, UR, Nene, S, Kulkarni, BD |
| Journal | Biochemical Engineering Journal |
| Volume | 27 |
| Issue | 1 |
| Pagination | 66-71 |
| Date Published | DEC |
| ISSN | 1369-703X |
| Keywords | 1, 4-benzodioxan-2-carboxylate, 4-benzodioxan-2-carboxylic acid, doxazosin, enantio selectivity, enantiomeric ratio, ethyl 1, ethyl acetate, Lipases, transesterfication |
| Abstract | Ethyl 1,4-benzodioxan-2-carboxylate is used as an intermediate compound for the production of drug doxazosin mesylate. The title compound was kinetically resolved to get S-enantiomer of ethyl 1,4-benzodioxan 2-carboxylate in a simple lipase catalyzed transesterificafion reaction. Ethyl acetate was used as reaction medium as well as acyl donor. The influence of the enzyme source and time of reaction on the enantio selectivity of product were studied. Lipase from Candida antartica-B (Novozyme A/S) catalyzed transesterification reaction with good enantio selectivity towards S-enantiomer. The high enantiomeric ratio, E= 160, provided S-2 an acceptable chemical yield (50%) and enaritiomeric excess (>95%). (c) 2005 Elsevier B.V. All rights reserved. |
| DOI | 10.1016/j.bej.2005.06.014 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.463 |
Divison category:
Chemical Engineering & Process Development