Convenient chemoenzymatic synthesis of (1S,7aS)-1-hydroxy-5-oxo-4-(2 `-carboxyethyl)-7a-methyltetrahydro-indane - a key intermediate of steroids
| Title | Convenient chemoenzymatic synthesis of (1S,7aS)-1-hydroxy-5-oxo-4-(2 `-carboxyethyl)-7a-methyltetrahydro-indane - a key intermediate of steroids |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Kalkote, UR, Purude, AN, Puranik, VG, Gurjar, MK |
| Journal | Journal of Molecular Catalysis B-Enzymatic |
| Volume | 40 |
| Issue | 1-2 |
| Pagination | 38-43 |
| Date Published | MAY |
| Type of Article | Article |
| ISSN | 1381-1177 |
| Keywords | chemoenzymatic method, Enzymatic hydrolysis, steroids, terpenoids |
| Abstract | A porcine pancreatic lipase mediated enzymatic hydrolysis of (+/-)-1-acetoxy-5-oxo-4-(2 `-carbomethoxyethyl)-7a-methyltetrahydroindane (5b) furnished (1S,7aS)-1-acetoxy-5-oxo-4-(2 `-carbomethoxyethyl)-7a-methyltetrahydro-indane (9) and (1R,7aR)-1-hydroxy-5-oxo-4-(2 `-carbomethoxyethyl)-7a-methyltetrahydro-indane (8) with > 99% e.e. which on further chemical hydrolysis gave 1 and ent-1, key intermediates of steroids. (c) 2006 Elsevier B.V. All rights reserved. |
| DOI | 10.1016/j.molcatb.2006.01.037 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.189 |
Divison category:
Center for Material Characterization (CMC)
Organic Chemistry