Short and practical enantioselective synthesis of linezolid and eperezolid via proline-catalyzed asymmetric alpha-aminooxylation
| Title | Short and practical enantioselective synthesis of linezolid and eperezolid via proline-catalyzed asymmetric alpha-aminooxylation |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Narina, SV, Sudalai, A |
| Journal | Tetrahedron Letters |
| Volume | 47 |
| Issue | 38 |
| Pagination | 6799-6802 |
| Date Published | SEP |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Abstract | An efficient enantioselective synthesis of the antibacterials, linezolid (U-100766), and eperezolid (U-100592) using D-proline-catalyzed asymmetric alpha-aminooxylation of aldehydes as the key step is described here. This is the first report on the enantioselective synthesis of linezolid and eperezolid using asymmetric catalysis. (c) 2006 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2006.07.065 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Chemical Engineering & Process Development