Stereoselective synthesis of (S)-dapoxetine starting from trans-cinnamyl alcohol

TitleStereoselective synthesis of (S)-dapoxetine starting from trans-cinnamyl alcohol
Publication TypeJournal Article
Year of Publication2008
AuthorsVenkatesan, K, Srinivasan, KV
JournalArkivoc
Pagination302-310
Date PublishedJAN
Type of ArticleArticle
ISSN1424-6376
Keywords(S)-dapoxetine, antidepressant, Sharpless asymmetric epoxidation, stereoselective synthesis
Abstract

A novel stereoselective synthesis of (S)-dapoxetine starting from commercially available trans-cinnamyl alcohol is described. Sharpless Asymmetric Epoxidation (SAE) is utilized as the key step in this synthetic strategy.

Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)1.177
Divison category: 
Organic Chemistry