Asymmetric synthesis of (S)-vigabatrin (R) and (S)-dihydrokavain via cobalt catalyzed hydrolytic kinetic resolution of epoxides
| Title | Asymmetric synthesis of (S)-vigabatrin (R) and (S)-dihydrokavain via cobalt catalyzed hydrolytic kinetic resolution of epoxides |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | I. Raj, VPaul, Sudalai, A |
| Journal | Tetrahedron Letters |
| Volume | 49 |
| Issue | 16 |
| Pagination | 2646-2648 |
| Date Published | APR |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Abstract | A concise route to the asymmetric synthesis of (S)-vigabatrin(R) and (S)-dihydrokavain has been described using Co-catalyzed hydrolytic kinetic resolution of racemic epoxides and regiospecific opening of terminal epoxides with dimethylsulfonium methylide as the key steps. (C) 2008 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2008.02.064 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Chemical Engineering & Process Development