Co-catalyzed mild and chemoselective reduction of phenyl esters with NaBH(4): a practical synthesis of (R)-tolterodine
| Title | Co-catalyzed mild and chemoselective reduction of phenyl esters with NaBH(4): a practical synthesis of (R)-tolterodine |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Jagdale, AR, Sudalai, A |
| Journal | Tetrahedron Letters |
| Volume | 49 |
| Issue | 23 |
| Pagination | 3790-3793 |
| Date Published | JUN |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Abstract | CoCl(2) catalyzes effectively the chemoselective reduction of phenyl carboxylic esters to the corresponding saturated alcohols in high yields using NaBH(4) at ambient conditions. By employing this methodology, the synthesis of (R)-tolterodine, a muscarinic receptor antagonist, has been achieved in high yield and optical purity. (C) 2008 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2008.04.007 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Chemical Engineering & Process Development