Organocatalytic enantioselective synthesis of beta-blockers: (S)-propranolol and (S)-naftopidil
| Title | Organocatalytic enantioselective synthesis of beta-blockers: (S)-propranolol and (S)-naftopidil |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Panchgalle, SP, Gore, RG, Chavan, SP, Kalkote, UR |
| Journal | Tetrahedron-Asymmetry |
| Volume | 20 |
| Issue | 15 |
| Pagination | 1767-1770 |
| Date Published | AUG |
| ISSN | 0957-4166 |
| Abstract | An efficient enantioselective synthesis of beta-adrenergic blockers (S)-propranolol and (S)-naftopidil with > 98% ee using an L-proline-catalyzed alpha-aminoxylation of an aldehyde as a key step is described. (c) 2009 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetasy.2009.07.002 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.484 |
Divison category:
Organic Chemistry