Synthesis and in vitro study of 14-aryl-14H-dibenzo[a.j]xanthenes as cytotoxic agents
| Title | Synthesis and in vitro study of 14-aryl-14H-dibenzo[a.j]xanthenes as cytotoxic agents |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Bhattacharya, AK, Rana, KC, Mujahid, M, Sehar, I, Saxena, AK |
| Journal | Bioorganic & Medicinal Chemistry Letters |
| Volume | 19 |
| Issue | 19 |
| Pagination | 5590-5593 |
| Date Published | OCT |
| ISSN | 0960-894X |
| Keywords | Aldehyde, beta-Naphthol, condensation, Cytotoxicity, One-pot reaction, Solvent-free, Tantalum(V) chloride, Xanthenes |
| Abstract | A simple and expedient method for the synthesis of a series of 14-aryl-14H-dibenzo[a.j]xanthenes is described through a one-pot condensation of beta-naphthol with aryl aldehydes catalysed by TaCl(5) under solvent-free conventional heating. The major advantages of the present method are: high yields, less reaction time, solvent-free condition and easy purification of the products. The synthesized 14-aryl-14H-dibenzo[a.j]xanthenes were evaluated against a panel of six human cancer lines of different tissues. Synthesized compound 30 showed IC(50) of 37.9 and 41.3 mu M against Colo-205 and 502713, respectively, whereas 3g showed IC(50) of 41.9 mu M against Colo-205. (C) 2009 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.bmcl.2009.08.033 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.661 |
Divison category:
Biochemical Sciences
Organic Chemistry