Syntheses and biological evaluation of new triazole-spirochromone conjugates as inhibitors of mycobacterium tuberculosis
| Title | Syntheses and biological evaluation of new triazole-spirochromone conjugates as inhibitors of mycobacterium tuberculosis |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Muthukrishnan, M, Mujahid, M, Yogeeswari, P, Sriram, D |
| Journal | Tetrahedron Letters |
| Volume | 52 |
| Issue | 18 |
| Pagination | 2387-2389 |
| Date Published | MAY |
| ISSN | 0040-4039 |
| Keywords | Antitubercular activity, Click chemistry, Mycobacterium tuberculosis, Spirochromones |
| Abstract | A series of novel 1,2,3-triazole fused spirochromone conjugates have been synthesized bearing both spirochromone moiety as well as a 1,2,3-triazole moiety. Some of the compounds have exhibited potential activity against Mycobacterium tuberculosis (virulent strain H37Rv). In particular 5e proved to be the most potent derivative exhibiting MIC = 0.78 mu g/mL. (C) 2011 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2011.02.099 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.683 |
Divison category:
Organic Chemistry