Analysis of AGE modified proteins and RAGE expression in HER2/neu negative invasive ductal carcinoma
| Title | Analysis of AGE modified proteins and RAGE expression in HER2/neu negative invasive ductal carcinoma |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Korwar, AM, Bhonsle, HS, Chougale, AD, Kote, SS, Gawai, KR, Ghole, VS, Koppikar, CB, Kulkarni, MJ |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 419 |
| Issue | 3 |
| Pagination | 490-494 |
| Date Published | MAR |
| ISSN | 0006-291X |
| Keywords | advanced glycation end products, Breast cancer, RAGE |
| Abstract | Cancer is associated with increased glycolysis and carbonyl stress. In view of this, AGE modified proteins were identified from clinical breast cancer tissue using 2DE-immunoblot and mass-spectrometry. These proteins were identified to be serotransferrin, fibrinogen gamma chain, glycerol-3-phosphate dehydrogenase, lactate dehydrogenase, annexin II, prohibitin and peroxiredoxin 6, which have established role in cancer. Further, RAGE expression and its downstream signaling proteins NADPH oxidase and NF-kB were studied. Role of these AGE modified proteins and RAGE signaling in breast cancer is discussed. (C) 2012 Elsevier Inc. All rights reserved. |
| DOI | 10.1016/j.bbrc.2012.02.039 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.406 |
Divison category:
Biochemical Sciences