Dimensionality reduction in computational demarcation of protein tertiary structures
Title | Dimensionality reduction in computational demarcation of protein tertiary structures |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Joshi, RR, Panigrahi, PR, Patil, RN |
Journal | Journal of Molecular Modeling |
Volume | 18 |
Issue | 6 |
Pagination | 2741-2754 |
Date Published | JUN |
ISSN | 1610-2940 |
Keywords | Logistic regression, Principal component analysis, Protein structural classes, Quantitative features of tertiary folds, SCOP database |
Abstract | Predictive classification of major structural families and fold types of proteins is investigated deploying logistic regression. Only five to seven dimensional quantitative feature vector representations of tertiary structures are found adequate. Results for benchmark sample of non-homologous proteins from SCOP database are presented. Importance of this work as compared to homology modeling and best-known quantitative approaches is highlighted. |
DOI | 10.1007/s00894-011-1223-0 |
Type of Journal (Indian or Foreign) | Foreign |
Impact Factor (IF) | 1.984 |
Divison category:
Biochemical Sciences