Short synthesis of (2S,3S)-3-hydroxypipecolic acid

TitleShort synthesis of (2S,3S)-3-hydroxypipecolic acid
Publication TypeJournal Article
Year of Publication2013
AuthorsChavan, SP, Harale, KR, Pawar, KP
JournalTetrahedron Letters
Volume54
Issue36
Pagination4851-4853
Date PublishedSEP
Type of ArticleArticle
ISSN0040-4039
KeywordsReductive lactamization, Selective deprotection, Wittig reaction
Abstract

A convenient synthesis of (2S,3S)-3-hydroxypipecolic acid starting from cheap and abundant L-(+)-tartaric acid has been achieved. The strategy employs selective ester reduction and reductive lactamization as key steps. (C) 2013 Elsevier Ltd. All rights reserved.

DOI10.1016/j.tetlet.2013.06.111
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)2.391
Divison category: 
Organic Chemistry