Capturing a novel metastable polymorph of the anticancer drug gefitinib
| Title | Capturing a novel metastable polymorph of the anticancer drug gefitinib |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Thorat, SH, Patwadkar, MV, Gonnade, RG, Vaidhyanathan, R |
| Journal | CrystEngComm |
| Volume | 16 |
| Issue | 37 |
| Pagination | 8638-8641 |
| Date Published | AUG |
| Type of Article | Article |
| ISSN | 1466-8033 |
| Abstract | Gefitinib, a life-extending anticancer drug, exhibits solvent-mediated conformational polymorphism to yield stable (form I) and novel metastable (form II) polymorphs. Crystal structure analysis revealed 3D isostructurality in the molecular organization of the polymorphs, and the metastable polymorph undergoes a crystal-to-crystal thermal phase transition to the stable polymorph. |
| DOI | 10.1039/c4ce01446d |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.849 |
Divison category:
Physical and Materials Chemistry