Formation of a pseudo-beta-hairpin motif utilizing the Ant-Pro reverse turn: consequences of stereochemical reordering
| Title | Formation of a pseudo-beta-hairpin motif utilizing the Ant-Pro reverse turn: consequences of stereochemical reordering |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Nair, RV, Kotmale, AS, Dhokale, SA, Gawade, RL, Puranik, VG, Rajamohanan, PR, Sanjayan, GJ |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 12 |
| Issue | 5 |
| Pagination | 774-782 |
| Date Published | FEB |
| ISSN | 1477-0520 |
| Abstract | Herein, we report a special case of pseudo-beta-hairpin formation by tetrapetide sequences featuring a two-membered Ant Pro dipeptide motif (Ant = anthranilic acid and Pro = proline) at the loop region. These folded structures uniquely feature the presence of C9- and C17-H-bonding patterns at reverse turn and interstrand regions, respectively. Their hairpin nucleation and folding propensities have been expounded using solution and solid state studies of distinct stereochemically altered sequences. |
| DOI | 10.1039/c3ob42016g |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.93 |
Divison category:
Center for Material Characterization (CMC)
Central NMR Facility
Organic Chemistry